ea0022p64 | Adrenal | ECE2010
Schwafertz Carolin
, Schinner Sven
, Kuhn Markus
, Ansurudeen Ishrath
, Oetjen Elke
, Schott Matthias
, Scherbaum Werner A
, Willenberg Holger S
Objective: Recently, we have shown that endothelial cell-conditioned medium (ECCM) stimulates aldosterone secretion and the expression of proteins, essential for steroidogenesis and adrenal development. Also, we have found that fat cells regulate adrenal steroidogenesis through the wnt-signaling pathway. In addition, β-catenin was implicated in adrenal tumorigenesis, including aldosterone-producing adenomas.Methods: We studied the influence of endot...